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BIO-0013 (103)
Lecture

19.3, 19.4, 19.5 Class Notes.docx

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Department
Biology
Course
BIO-0013
Professor
Michelle Gaudette
Semester
Fall

Description
November 26, 2013 Enhancers bind to activators Northern Blotting • Need to know the specific sequence you are expecting • Need a probe to see  • Tells you if a gene is being transcribed or not Introns can contain enhancers that are necessary for transcription to occur Rules for enhancers: • Enhancers act over long distances (positive control) • In any orientation • Can be located in introns or in untranscribed 5’ or 3’ sequences flanking the gene • Many types of enhancers exist (different for different genes) • Can work if moved to new location near original gene • Opposite function  ▯silencers (negative control) o Repressor transcription factors bind to these To regulate the transcription of a gene, specific regulatory proteins need to bind to the correct  DNA sequences (e.g. enhancers, silencers, promoter proximal element) • Enhancer  ▯activator protein • Silencer  ▯repressor protein  You get the best initiation if you have the entire transc
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