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BIO-0013 (103)
Lecture

16.4, 17.1, 17.2, B16, Northern Blotting Class Notes.docx

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Department
Biology
Course
BIO-0013
Professor
Michelle Gaudette
Semester
Fall

Description
November 12, 2013 Mutation – any permanent change in an organism’s DNA Original DNA  ▯DNA with a conflicting mismatch  ▯one strand of normal DNA, one strand of  mutant DNA Missense mutation ­ point mutations that cause a change in the amino acid sequence of a protein Silent mutation – change in nucleotide that does not change amino acid sequence Nonsense mutation – change in nucleotide that results in an early stop codon Frameshift mutation – addition or deletion of a nucleotide Transcription of a gene – production of a RNA (short­lived version of archived instructions in  DNA) The sequence of nucleotides in mRNA is then translated into a sequence of amino acids (protein) Transcription: • Requires NTPs (ribonucleoside triphosphates) with ribose as a sugar • NO primer is needed • In prokaryotes: o You need:  DNA template: • Start – promoter • Stop – termination signal for RNA polymerase  RNA polymerase and NTPs  Sigma factors o RNA polymerase: catalyzes the form
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