Class Notes (839,147)
United States (325,796)
Biology (196)
BIO-0013 (103)
Lecture

12.3, 12.4, 15.2, 15.3 Class Notes.docx

2 Pages
105 Views

Department
Biology
Course Code
BIO-0013
Professor
Michelle Gaudette

This preview shows 80% of the first page. Sign up to view the full 2 pages of the document.
Description
October 8, 2013 G 1can vary a lot depending on the type of cell (all other stages stay pretty much the same) MPF = mitotic cyclin + cyclin­dependent kinase (cdk)  • Two phosphate groups are added to the cdk during G 2 o One promotes kinase activity o One inhibits kinase activity o When the inhibitory phosphate is removed, MPF becomes active  o Look at the chart on slide 3 Checkpoints prevent the cell from progressing inappropriately through the cell cycle • G2 – if chromosomes have replicated successfully, DNA is undamaged, and activated  MPF is present • M­phase – pass if (1) chromosomes have attached to spindle apparatus and (2)  chromosomes have properly segregated and MPF is absent • G1 checkpoint – pass if cell size is adequate, nutrients are sufficient, social signals are  present, DNA is undamaged o A G  checkpoint ensures that cells are ready to begin DNA synthesis 1 1. Growth factors arrive from other cells 2. Growth factors cause increase in cyclin and E2F concentrations 3. Cyclin binds to cdk; cdk is phosphorylated.  Rb inactivates E2F by  binding to it a. Rb is a molecular brake 4. Inactivating phosphate is removed, and active cdk phosphorylates Rb 5. Phosphorylated Rb releases E2F 6. E2F triggers production of S­phase proteins o Look at cycle on slide 5 Fluorescen
More Less
Unlock Document

Only 80% of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit