BIO-0046 Lecture 6: Ion Transport and Calcium Signaling
Document Summary
One type of gpcr results in the opening of an ion channel. The ion channel that is opens causes the cell to become hyperpolarized. If any of these lead to the hallmarks of cancer, we can start to define thing as oncogenes, tumor suppressors, etc. Coupled transporter: uses energy released as one ion moves down its electrochemical gradient to push another against its gradient o o o o o o o o o. Concentration of k+ is higher inside the cell. Passive transport, so k+ follows concentration gradient and moves out. Loss of + ions leads to more negative inside of cell! Big picture: entire signaling pathway is essential in relaying signal. We can mutate any one of these parts and it"ll effect the product. Uses atp hydrolysis to drive ions across membrane against gradient. 3 na+ move out for every 2 k+ we pump in.
