BIO-0013 Lecture Notes - Lecture 11: Martha Chase, Dna Replication, Nucleoside
Document Summary
How do we know dna is the hereditary material, martha chase and alfred hershey used t2 bacteriophage - virus that infects bacteria. First the virus genes, which are located in the virus capsid, enter the host cell(virus capsid stays on the outside of the cell and injects the genes inside) Third, new generation of virus particles bursts from host cells. Bacteria is in the pellet with the genetic information from the virus: radioactive dna ended up in the pellet since it was far heavier. Each strand of a dna can serve as a template for the formation of a new strand. If the hydrogen bonds between complementary base pairs are broken, 2 templates are given. Synthesize 5" to 3": determining the correct model of dna replication. Leading strand synthesizes 5" to 3": builds dna towards the 3" end of the template strand, made in the same direction the fork is opening, one continuous strand that doesn"t stop.
