NSCI 3310 Lecture Notes - Lecture 22: Protein Kinase C, Protein Kinase A, Adenylyl Cyclase
17 Feb 2016
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Single subunit, but can form and signal as dimers. Receptor binding g protein activation 2nd messenger activation kinase activation phosphorylation of channel protein. 2012 nobel prize in chemistry awarded to brian kobilka and robert lefkowitz for their work characterizing the function of gpcrs. (1) shunting inhibition slide from previous lecture (postsynaptic mechanisms of synaptic transmission lecture) Opening of ion channels independent of changing the membrane potential. Can be expressed by ohm"s law, v = ir. >when we activate chloride channels at gaba synapses, we decrease r (membrane resistance) due to the number of open channels, giving us a proportionately smaller v (membrane potential) >changes the neuron"s excitability >makes it less excitable to synaptic input. Reversal potential is positive to threshold for ap generation. Chloride potential is negative to threshold this is why this shunting inhibition works; cl- never excitatory (2) current slide. Synaptic modulation = activation of g-protein-coupled receptors (gpcrs)
