BIO 115 Lecture Notes - Lecture 4: Bronchiole, Congenital Pulmonary Airway Malformation, Congenital Diaphragmatic Hernia
Document Summary
Heterogeneous group of congenital cystic and non-cystic lung masses characterized by extensive overgrowth of the primary bronchioles. Most frequently found in the lower lobes, usually only in 1 lobe. 0: dysplasia of large airways, diffuse/small cysts occupying entire lung, rare and incompatible with life. I: arises from distal bronchi or proximal bronchioles, well-differentiated tissue, single or multiple thin-walled cysts, generally confined to one lobe, may have mass effect. Ii: arises from terminal bronchioles, multiple small cysts with solid areas, identical to ps except with pulmonary blood supply, associated with other congenital disorders. Iii: arises from distal broncho-alveolar tissue, uncommon, solid-- resembles a tumor, may be large and occupy multiple lobes, severe respiratory distress in newborns. An over-inflation or distention of one or more of pulmonary lobes that causes progressive respiratory distress. Mass effect causing bronchial narrowing and air trapping. Developmental discontinuity in the diaphragm that causes abdominal viscera to herniate into the chest.
