BIO 115 Lecture Notes - Lecture 27: Cetirizine, Vascular Smooth Muscle, Azelastine
Document Summary
Using the drug list (currently-important antihistamines, page 3) as a guide, recognize the names of the specific h1 receptor antihistamines in clinical use. First generation h1 receptor blockers - anti-muscarinic and cns sedative effects. Second generation - no antimuscarinic, no sedative effects (-dine, -tine) Describe the signal transduction processes by which binding of histamine to h1 and h2 receptors is transduced into physiological responses and the biological effects of histamine and its antagonists at these receptors. Vascular smooth muscle- the triple response of lewis. Flare surrounding it - indirect vasodilation via substance p and. Wheal - raised area indicating fluid leaking, H2 receptor activates the cell to release hcl. Vagal stimulation, ecl cell activation, or gastrin release can cause. Cns result of anti-histamine drugs is due to the antimuscarinic effects. Muscarinic binding causes large airway constriction. treat with. Second messenger phospholipase c calcium liberation. Second messenger adenylyl cyclase convert atp to camp.
