BSC 300 Lecture Notes - Lecture 22: Algae, Cdc42, Dynactin
18 Apr 2018
School
Department
Course
Professor
Document Summary
Cell organization and movement ii: microtubules and intermediate filaments: Op18/stathmin, which enhance catastrophe frequency: microtubule-associated proteins (maps, maps comprise a heterogeneous group of proteins, maps attach to the surface of microtubules to increase their stability and promote their assemble. Spacing of microtubules depends on the length of the projection domains of microtubule associated proteins: map (long arm) and tau (short arm) side-binding proteins-- stabilize and space mts, map-mt associations: Spacing reflects difference between the lengths of the map2 and tau projection domains. Important concepts to remember about kinesins and dyneins: microtubule-based motor. Involved in organelle transport: kinesin-2, family has two closely related but nonidentical heavy chains and a third cargo-binding subunit, kinesin-5 family, four heavy chains assembled in a bipolar configuration can slide antiparallel microtubules past each other, kinesin-13 family: Inhibited form: head folds back and interacts with the tail. Step 1: motor binding to vesicle receptor unfolds kinesin, activating atpase activity.
