BSC 300 Lecture Notes - Lecture 7: Secretion, Cell Membrane, Signal Peptide

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Bonds catalyzed by the protein disulfide isomerase (more info later in lecture) Bsc 300-001 week 7 notes: transient interactions between receptors and fg-repeats allow rapid diffusion of nuclear transport receptor-cargo complexes through the central channel of the npc ix. Cargo can only move through nuclear pores when bound to escort protein called importin: unidirectional movement driven by generation of gradients of. Cargo/importin complexes that is high on the cytoplasmic side of the nuclear envelope xi. Importin is recycled back to the cytoplasm through association with asmall. Ran hydrolysis of gtp in the nucleus and exchange of gdp for gtp n the cytoplasm maintains these gradients that faceilitate movement into the nucleus xiii. Recall g proteins are activation switches for other proteins, they other proteins, they bind and activate target proteins only when association with a small g protein called ran xiv.

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