BSC 300 Lecture Notes - Lecture 9: Cgmp-Dependent Protein Kinase, Protein Kinase B, Cell Membrane
Document Summary
Bsc 300-001 week 9 notes: gtpase switch proteins (aka g proteins) that allosterically regulate target proteins (found in all prokaryotic and eukaryotic cells, about, exist in two forms, active on position bound. Bsc 300-001 week 9 notes intercellular proteins (ras, ran, sar, etc: switching mechanism of monomeric g proteins, on-off transition conformational changes in the ras monomeric g protein, switch i and ii constitute the. 11-cis-retinal: when 11-cis-retinal absorbs a photon it rapidly isomerizes to the all-trans isomer, this induces a conformational change in rhodopsin to the activated unstable intermediate meta- rhodopsin ii, meta-rhodopsin ii binds its cognate heterotrimeric. G-protein generating g t gtp (transducin: the all-trans-retinal moiety quickly dissociated from opsin unstable covalent linkage cleaves spontaneously. Gmp, dramatically lowering cgmp concentration: cgmp dissociates from cation channels and influx of na+ and. Gdp, which reestablishes the inactive heterotrimeric g-protein: pde is deactivated and cgmp accumulates.