BSC 300 Lecture Notes - Lecture 10: Protein Kinase B, Phosphatidylinositol 4,5-Bisphosphate, Protein Kinase A
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One example is protein kinase b: protein kinase b (aka akt) binds pi 3,4-bisphosphate via an interaction domain called the ph (plectin homology) domain, which normally hides its kinase catalytic domain, b is now activated. Bsc 300-001 week 10 notes: binding exposes pkb ser/thr residues that are phosphorylated by another. Pi3,4-bp activated kinase pdk1 (and a cytoplasmic pdk2). ix. Once activated pkb dissociates and phosphorylates its target genes in a cell type dependent manner. Bsc 300-001 week 10 notes: it is a dynamic system composed of three principle types of fibers. G-actin: found in all eukaryotes and some bacteria, ancient family of proteins, found in all eukaryotes and evolutionarily related to a bacterial protein (mreb) which produces filaments found in their cell walls. Mg lobes. dependent manner, and contacts both: g-actin is an atpase, and its hydrolysis of. Atp plays an important role in microfilament dynamics.