BSC 300 Lecture Notes - Lecture 15: Tumor Suppressor Gene, Evolutionary Arms Race, Dna Replication
10 Dec 2018
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Document Summary
No single mutation is cancer-causing: this usually takes many years, therefore most cancer is a disease associated with advanced age. However, some mutations are more oncogenic than others and can lead to development much earlier in life. A single cell acquires mutations that allow it to begin proliferating outside of the controls of normal. If it evades the immune system, it can establish a tumor, a benign pool of precancerous cells. Rampant chromo breakage and random stitching together or the pieces produces dozens to hundreds of chromo fragments in odd combos: cancers have highly abnormal karyotypes, chromo of most cancer cells are dramatically altered. Bsc 300-001 week 15 notes prominent nucleoli, increased percentage of mitotic cells and little differentiated structures: the increase in gene copy number, due to chromo and regional duplications, leads to higher protein production that alters cell physiology. It has a high km, therefore does not turn over pyruvate quickly.
