BSC 422 Lecture Notes - Lecture 11: Laser Ablation, Ionizing Radiation, High-Intensity Focused Ultrasound
19 May 2018
School
Department
Course
Professor
Prevention
Don’t Do that
• Smoking
• Sunburn
• Carcinogenic chemicals
• Ionizing radiation
o Smoking
o Radon
• Chronic irritation
o Alcohol to excess
• Infectious disease
Be Healthy
• Low fat intake
• High fiber
• Antioxidants
• Anti inflammatory
• Low stress
• Moderation
Treatment
Basic Types
• Surgery
o Curative is not metastasized and if all removed
o Side effects: depends on what and how much is removed
o How removed
▪ Laser ablation
▪ Cryosurgery
▪ High-intensity focused ultrasound
• Heats targeted tissue
• Radiation
o Usually ionizing radiation
▪ Creates free radicals
▪ Cause mutations
o If active, p53
▪ Detects DNA damage
▪ Induce apoptosis
▪ Many tumors are tumors because of defects in p53 genes
o High dose radiation induce severe DNA damage
▪ Cells prevented from dividing (mitotic death)
o Selective toxicity achieved by targeting
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