BSC 431 Lecture Notes - Lecture 27: Non-Gonococcal Urethritis, Sinusitis, Headache

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Chlamydia (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) C. psittaci- bird reservoir, pneumonia and systemic disease. Unique developmental life cycle: exist in 2 forms: Lack peptidoglycan in an otherwise gram negative-like cell wall; lps is shortened (cid:1) Attach to receptors on epithelial cells in mucous membranes via microvilli and stimulate uptake (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Mitochondria become associated w/ the endosome membrane providing atp (cid:1) W/in 6-8 hours, the transistion from elementary body to reticulate body occurs. Replication via binary fission produces micro colony called an inclusion (cid:1) (cid:1) body (cid:1) After 18-24 hours, the rbs reorganize into ebs and the cell ruptures (48-72 hours) (cid:1) Steps in pathogenesis: attachment and phagocytosis, phagosome-lysosome fusion inhibited, conversion from ebs to rbs, growth & division, conversion from rbs to ebs, release of ebs from host cell either by lysis or reverse endocytosis, trachomatis.