BSC 431 Lecture Notes - Lecture 26: Causative, Bartonella Henselae, Cat-Scratch Disease

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Rickettsia and orientia (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) and. Unable to grow w/o a living host cell. Very small: 0. 3 micrometers x 1-2 micrometers. Stain poorly w/ gram stain: rickettsia has minimal pg and lps but orientia lacks both. Divided into 2 main groups: spotted fever & typhus: spotted fever group- rickettsia spp. Restricted geographic distribution: typhus group- rickettsia ssp. Worldwide distribution: scrub typhus group- orientia ssp. Most common cause of rickettsial disease in the us. Organism is introduced to humans via tick bites, enters cells by (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) stimulating phagocytosis (cid:1) Degrade the phagosome membrane by phospholipase activity to get into the cytoplasm (cid:1) Disease is caused by the replication of the bacteria in host endothelial cells w/ subsequent damage to the cells and leakage of the blood vessels (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) 6+ hours of tick exposure is required to transfer the bacteria.