BIO 201 Lecture Notes - Lecture 20: Pyruvate Dehydrogenase, Citric Acid Cycle, Cellular Respiration

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Evolved when o2 levels increased in atmosphere. Go through glycolysis to get to pyruvate. Only when o2 is present, pyruvate goes through oxidation co2. Harvest energy in nadh and fadh2 to make atp. Not in anaerobic organisms or absence of o2! Pathways of aerobic metabolism: pyruvate decarboxylation, citric acid cycle (aka krebs cycle/tricarboxylic acid (tca) cycle, electron transport system. Capture energy from nadh and fadh2 to create h+ gradient: atp synthesis. ~ 30 more atp than glycolysis alone. Can only occur in presence of o2!! Pyruvate decarboxylation and cac ---> oxidation of pyruvate. Anatomy of pyruvate oxidation and citric acid cycle. Pyruvate oxidation and cac happens in matrix. Energy harnessed to make gtp (atp), nadh, and fadh2. In aerobic bacteria and archaea, occurs in cytoplasm. In eukaryotes, occurs in mitochondrial matrix (derived from cytoplasm of aerobic bacteria refer back to endocytosis of aerobic bacteria) Inner membrane is highly folded (cristae) derived from plasma membrane from original bacterium.

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