BIO 205 Lecture Notes - Lecture 31: Pyruvate Decarboxylase, Ethanol Fermentation, Alcohol Dehydrogenase
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3 May 2018
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Lecture 31 Pyruvate Fates
Role of Pyruvate
1. Aerobic vs anaerobic fates of pyruvate
a. PDH converts pyruvate into acetyl-CoA
b. Anaerobic metabolism: when lactic acid builds up in muscle cells
c. Aerobic process generates 38 ATP
d. Anaerobic process generates only 2 ATP
2. Cellular locations of different pathways
a. Fermentation occurs in cytoplasm
b. Aerobic process occurs in the mitochondrion
Fermentation
3. Need to recycle NADH in anaerobic fermentation
a. Glycolysis we get 2 ATP net
b. In glycolysis, NAD+ is consumed to make NADH
c. The only way to get more NAD+ is to change NADH back to
NAD+
4. Same C:H ratios: glc vs fermentation products
a. From glucose to lactate the C:H ratio is the same
5. Alcoholic fermentation: reactions and enzymes
a. Pyruvate decarboxylase
b. Alcohol dehydrogenase: aldehyde changed to alcohol
6. Yeast and bacterial competitors: murder
a. Aerobic=lots of ATP made, synthesis energy=cell division=more
yeast
b. Anaerobic=ethanol production
7. Lactate fermentation
a. Lactate fermentation produces deprotonated negatively charged
organic molecules and H+, H+ lowers the pH in muscle cells and
causes pain
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