BIO 319 Lecture Notes - Lecture 4: Reactive Oxygen Species, Superoxide Dismutase, Epistasis

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Bio319 genetics - study guide for unit 4, lecture 31 - chapter 18. 1-18. 4. Base substitution a point mutation in which one base is substituted for another. Silent mutation a dna sequence that does not alter the amino acid sequence of the encoded polypeptide even though the nucleotide sequence has changed. Missense mutation a base substitution that leads to a change in the amino acid sequence of the encoded polypeptide. Example: sickled rbc, the 20nt of gene for beta chain of hemoglobin alter gag(glu) gtg(val) Neutral mutation a mutation that has no detectable effect on protein function or no detectable effect on the survival of the organism. Nonsense mutation a mutation that involves a change from a sense codon to a stop codon. Frameshift mutation a mutation that involves the addition or deletion of nucleotides not in a multiple of three and thereby shifts the reading frame of the codon sequence downstream from the mutation.

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