BIO 201 Lecture Notes - Lecture 28: Paclitaxel, Tumor Suppressor Gene, Dna Replication
23 Apr 2017
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Document Summary
Spindle assembly checkpoint right in the middle of m phase (between metaphase and. Chromosomes segregate toward 2 halves of the cell. If anything goes wrong during this step, bad things happen. Abnormal segregation of chromosomes leads to chromosomal nondisjunction. Karyotype: number and types of chromosomes in a cell. Normal karyotype is usually compatible with life. Abnormal number of chromosomes in cell = cell sees it as dna damage. Aneuploidy: abnormal number and/or type of chromosomes(s); usually incompatible with life. Nondisjunction: abnormal chromosome segregation during mitosis or meiosis. One pair of sister chromatids fail to disjoin end up in same daughter cell. The protein complex that hold sister chromatids together at centromere. Protein in kinetochore that hold sister chromatids together until anaphase. Degraded by proteases as soon as the spindle is complete and chromosomes are aligned allows sister chromatids to segregate to 2 halves of the cell. How cell knows when it is time to degrade cohesin.
