BIO 205 Lecture Notes - Lecture 5: Toxicodendron Radicans, Amphiphile, Mutation
7 Mar 2018
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Lecture 5: water as a solvent: hydrogen bonds between water molecules, electronegativity, h-o polar. C=o polar: n-h polar, polar nature of water, ice: each water involved in four hydrogen bonds, flickering hydrogen bonds in liquid water, melting pts and boiling pts, methane is nonpolar. Ammonia is polar: melting pts in polar water and polar ammonia are higher than nonpolar methane, hydrophobic effect, interactions in biology. Individual subunits -> oligomer: concanvalin a: formation of tetramers from protein dimers. Buries nonpolar groups away from the aqueous solvent. Protein becomes more organized: noncovalent bonding interactions are made between proteins, solvent effects, melting: solvent lattice, add heat to break water-water hydrogen bonds, 2 protein dimers are organized, many waters become randomized. Exposed nonpolar surface: nonpolar surface is a quiet nondistracting environment, extra hydrogen bonds between waters, ice-like lattice, organized solvent layer. Trypsin inhibitor helix: 3. 6 residues are required to make one complete turn around the outside of the cylinder.
