BIO 205 Lecture Notes - Lecture 26: Futile Cycle, Thermogenin, Phosphofructokinase
21 Apr 2018
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Bypass i spends two atp, 1 from step 10 and an additional atp. Acetyl-coa is an activator of gluconeogenesis bypass i. Molecules that are activators are generally inhibitors of gluconeogenesis. Steps of glycolysis that need to be bypassed are steps 1,3, and 10. The enzymes that catalyze step a and b of bypass i of gluconeogenesis are both named carboxylases. The enzyme which is named for the reverse direction is bypass i, step b. An enzyme that catalyzes the reaction atp + gdp -> adp + gtp would be expected to have delta g of zero. Considering steps 1,3, and 10 of glycolysis, plus bypasses i, ii and iii of gluco(cid:374)eoge(cid:374)esis, 6 of these are dow(cid:374)hill, all of the(cid:373) . The first half of bypass i spends an atp and energizes pyruvate by adding an extra carbon in the form of cooh. The reaction g6p -> glc + pi is catalyzed by a phosphatase.
