BIO 205 Lecture Notes - Lecture 34: Citric Acid Cycle, Portal Vein, Lymphatic System
Lecture 34: Fatty acid metabolism: breakdown and
synthesis
Beta-oxidation of fatty acids: transport and catabolism
1. Transport of nutrients into intestinal cells
a. Shot FA’s diffuse aoss lipid membranes
b. Log FA’s euie speial taspotes to help the ete the
epithelial cells
c. Oe iside, lipids ae oied with glyeol to ake TAG’s
which are chylomicrons particles released in the lymph system
2. Villi: anatomy
a. Transfer monosaccharides, aio aids, ad sall FA’s
b. Transfer large chylomicrons to lacteal vessels in the villi which
drain into lymph vessels in the submucosal layer under the villi
3. Transport of nutrients to the circulatory system
a. Capillaries carry nutrients to the hepatic portal vein, which
enters the liver
4. Caitie shuttle: igs FA’s ito itohodio
a. Transports FA
b. FA-S-CoA + HO-carnitine -> FA-O-carnitine + HS-CoA
c. Net effect:
i. FA-S-CoA -> FA-S-CoA
ii. Outside -> inside
5. Beta-oxidation steps resemble Krebs cycle steps
a. Acyl-CoA dehydrogenase
b. Enoyl-CoA hydratase
c. B- hydroacyl-CoA dehydrogenase
d. Thiolase
e. Succinate -> fumurate -> malate -> OAA
6. ATP yields for oxidation of palmitate (16 carbon FA)
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