MIC 301 Lecture Notes - Lecture 19: Corynebacterium Diphtheriae, Diphtheria Toxin, Middlebrook 7H10 Agar

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Gram posiive straight or slightly curved bacilli, frequently swollen at one or both ends (club shaped) very resistant to drying non-spore former binary ission (snapping division) characterisic v and l shaped igures chinese leters . Diphtheria toxin responsible for signs and symptoms of diphtheria. Avirulent c. diphtheriae infected by bacteriophage (tox+) lysogenic conversion. B fragment binds to speciic cell surface receptors of respiratory epithelium mediates transport of a fragment into cell. A fragment inhibits protein synthesis resuling in cell death. Clinical disease: localized infecion respiratory (pharyngeal diphtheria, systemic infecion toxemia (+) toxin in blood. Systemic spread of primary infecion heart myocardiis central nervous system nerve degeneraion ________> paralysis kidneys iltering inadequacies; kidney failure. Specimen swab cultures (nares, pharynx, and nasopharynx) Precipitaion reacion diphtheria toxin (anigen) and diphtheria anitoxin (anibody) Severe cases tracheotomy or intubaion to prevent sufocaion. Control/prevenion acive immunizaion toxoid vaccine (dpt) Pepidoglycan skeleton overlayed with layers of mycolic acid (waxy lipid)

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