BSCI 202 Lecture 3: BSCI202 Blood Lecture 2 (2-1-18)
22 Feb 2018
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Document Summary
Move in/out of blood cells via diapedesis. Respond to chemicals released by damaged tissues and wbc"s. Granulocytes: granules (dots) in cytoplasm (can be stained, lobed nuclei, neutrophils, eosinophils, basophils. Agranulocytes: lack visible granules, nuclei are spherical, oval, kidney shaped, lymphocytes, monocytes. Neutrophils: multilobed nuclei w/fine granules, 40-70% of leukocytes in blood, phagocytosis at active infection sites (engulf foreign cells/particles, secretes cytokines, stay in blood 7-10 hours, move to tissue for a few days, number increases during infection. Eosinophils: large brick-red cytoplasmic granules, phagocytes (mainly kill parasites via toxic enzyme release, 1-4% of leukocytes. Basophils: <1% of leukocytes, non-phagocytes, toxic enzymes released against large parasites, allergic reactions, histamine inflammation, heparin anticoagulant. Monocytes: macrophages, 4-8% of leukocytes, phagocytes, circulate in blood for a few hours, then tissues, become macrophages, wandering macrophages, fixed macrophages. Leukocytosis: wbc count above 11,000/mm3, usually indicates infection. Leukopenia: low leukocyte level, commonly caused by corticosteroids and anticancer agents. Derived from common hemocytoblast (multipotent stem cell)
