KNES 464 Lecture Notes - Lecture 8: Activation Energy, Reaction Rate, Non-Competitive Inhibition
16 Oct 2018
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Reactants have more energy than products (products have lower energy than reactants) Negative gibbs free energy (- delta g) Positives gibbs free energy (+ delta g) Atp hydrolysis-- atp adp + p + energy (exergonic) Actin myosin atpase (where the crosbridges are cycling: 75% of sketlal muscle energy, actin and myosin proteins is the biggest contribution as well (sarcomeres) Sodium potassium atpase maintain cellular membrane potential: pump na in one direction and potassium in another direction. Enzyme puts reactants in an orientation that makes the reaction more likely to happen. Chemical reactions require activation energy to initiate the raction. Ensymes lower the activation energy, making it more leikly for the reaction to start. Without the enzyme, the reaction would depend on random collisioms between the reactants to bring them into proper alignment. Site of regulation if you can regular enzyme activity, can regulate the site of what is happening.
