KNES 466 Lecture Notes - Lecture 9: Coronary Artery Disease, Peripheral Artery Disease, Coronary Circulation
2 Mar 2017
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Harvard alumni study: take home: risk decreases in all age groups as physical activity increases. However, reduction in risk is greater as age groups increase. 150 minutes of moderate (or 75 minutes vigorous) physical activity per week is the standard goal for risk reduction and overall health. Nitric oxide: one of primary functions of endothelial cells is to secrete nitric oxide, which is a powerful vasodilator. Normal components of artery (from inside out: endothelium. This is the piece that can be damaged and set up the site for fatty streaks and plaques to gather: media. Greatest thickness of layers of coronary artery: external elastic lamina, adventitia. Damage to endothelial lining of coronary artery is where disease roots itself. Not just limited to coronary ateries: pad (peripheral artery disease) Tobacco smoke: chemical irritants + co: co inhibits hb"s effectiveness, plus all the chemicals involved.
