BIL 255 Lecture Notes - Lecture 14: Retinitis Pigmentosa, Zebrafish, Paramecium
12 Mar 2018
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Document Summary
Injected fiber optic cable to mouse brain to control neurons: hypothalamus controls aggression, when the light from the fiber optic cable is off, mouse behaves normally. In retinitis pigmentosa, photoreceptors dies: solution is to use bipolar cells that serve as relay cells to also serve as the sensory cells. In clinical trials, mice regained some vision: light can also be used to alter the memories of cokehead mice. These transporters have a particular motif that lets them bind to the disorder proteins. Ran can bind to the cargo and export the cargo instead. It binds to a chaperonin and can"t move back out. Then a little bit more moves in, and another chaperonin binds it to it. Once bound, the protein cannot move back out. Er: cholesterol, there is a cholesterol-binding protein in er that associates with srebp. If there is cholesterol the protein remains bound to the er.
