BIL 255 Lecture Notes - Lecture 16: Mitochondrial Disease, Citric Acid Cycle, Electrochemical Gradient

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18 Apr 2020

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What evolved first- glycolysis or the electron transport chain? a)glycolysis b)electron transport chain c)they must have evolved simultaneously. Gluconeogenesis reverses glycolysis, but is not glycolysis in reverse. Cells store food molecules to prepare for periods of need. Glycolysis and citric acid cycle provide precursors for synthesis of molecules. Mitochondria are located near sites of high atp utilization. Electron-transport chains pumps protons across inner mitochondrial membrane. Citric acid cycle in the mitochondrial matrix generates high-energy electrons. Nadh donates its electrons to the electron-transport chain. High-energy electrons, generated during the citric acid cycle, power atp production. How do electrons drive the movement of protons across the mitochondrial membrane? a)they create a negative electric field b)they oppose the proton gradient c)they cause a conformational shift in proteins d)they transmit electricity. Electron carrier causes conformational changes that drive proton pump. Electrons removed from a molecule (oxidized) are passed to another molecule (reduced) Nadh strong e- donor, nad+ weak e- acceptor.

Related Questions

Question 18

The process that forms new glucose in the liver is called ...

	A.	glycogenolysis
	B.	Krebs cycle
	C.	lipolysis
	D.	gluconeogenisis
	E.	oxidative phosphorylation

Question 57

A person exercises in their âfat burning zoneâ for 4 hours at 35% VO₂peak. The O₂ cost of exercise at that work rate is 0.5L/minute. Following exercise the subject rewards himself with an ice-cream sundae (700kcal). The following statement is true(assume 5kcal/lit of O₂):

	A.	The subject is in neutral energy balance
	B.	The subject consumed fewer calories than they expended during exercise
	C.	The subject consumed more calories than they expended during exercise
	D.	Canât say

Question 52

The primary purpose of the citric acid cycle is...

		aerobic glycolysis
		gluconeogenesis using lactate
		the decarboxylation of carbon compounds to produce NADH.
		the shuttling of hydrogen ions through the inner mitochondrial membrane

Question 51

In aerobic ATP production, the role of oxygen is to...

		to keep the electron transport chain operational
		to accept electrons from the 3rd cytochrome and thereby oxidizing it so it can accept new electrons
		act as a oxidizing agent by accepting electrons from the electron transport chain and combining with hydrogen ions (protons)
		all of the above

Question 50

Glucose is necessary for fatty acid oxidation because...

		its derivative, pyruvate, is condensated with carbonic acid to form oxaloacetate, which in turn is a necessary carbon compound in the citric acid cycle
		it is needed to convert fatty acids to fatty acyl-CoA which in turn is oxidized to acetyl CoA
		glucose is decarboxylated into cytochrome oxidase which is a necessary intermediate in the citric acid cycle
		its derivative, acetyl CoA, is condensated with carbonic acid to form lactase, which in turn is a necessary carbon compound in the citric acid cycle

olivegoat873

20. All living things must maintain a constantinternal environment to function properly through the process of__. (Points : 2)

metamorphosis
alkalosis
homeostasis
cryogenesis

Question 21.21. Glucose, fructose, sucrose,starch and glycogen are all examples of ___. (Points : 2)

proteins
carbohydrates
lipids
nucleic acids

Question 22.22. Some insects can "walk onwater" because __. (Points : 2)

water has a high surfacetension
water is adhesive
water istransparent
water expands when itfreezes

Question 23.23. To overcome an energy barrierbetween reactants and products in a chemical reaction, energy mustbe provided to get the reaction started. This energy is called ___energy. (Points : 2)

potential
reaction
initiation
activation

Question 24.24. Where in the cell doesglycolysis takes place? (Points : 2)

lysosomes
cytoplasm
mitochondria
nucleus

Question 25.25. Photosynthesis uses sunlightto convert water and carbon dioxide into __. (Points : 2)

carbon dioxide andwater
oxygen and sugars
proteins and sugars
carbon dioxide andoxygen

Question 26.26. The _____ of photosynthesisare the _____ of cellular respiration. (Points : 2)

electrons, protons
pigments, products
products, reactants
elements, atoms

Question 27.27. The energy currency of thecell is __. (Points : 2)

glucose
ATP
starch
glycogen

Question 28.28. When blood glucose levelsdecrease (as between meals), what reserves are tapped first?(Points : 2)

glycogen
fats
steroids
amino acids

Question 29.29. When glucose is used as anenergy source, the largest amount of ATP is produced by the ____portion of the entire respiratory process. (Points : 2)

glycolytic
Kreb's cycle
acetyl-CoAformation
electron transportchain

Question 30.30. Pyruvic acid can be regardedas the end product of ____. (Points : 2)

glycolysis
fermentation
the Kreb cycle
the electron transportchain

Question 31.31. How can one increase the rateof a chemical reaction? (Points : 2)

Increase the activationenergy.
Cool the reactants.
Decrease the pH.
Add an enzyme(catalyst).

Question 32.32. A prokaryote has ___. (Points: 2)

membrane-boundorganelles
nucleus
mitochondria
a cell membrane

Question 33.33. Unlike animal cells, plantcells have __. (Points : 2)

cell membranes
cell walls
chromosomes
mitochondria

Question 34.34. Which of the followingrequires energy to move molecules across the cell membrane? (Points: 2)

diffusion
osmosis
active transport
passive transport

Question 35.35. The ___ is the site of proteinsynthesis. (Points : 2)

nucleus
ribosome
mitochondrion
cytoskeleton

Question 36.36. Diffusion of water through asemipermeable membrane is called __. (Points : 2)

osmosis
diffusion
active transport
passive transport

Question 37.37. Which component of a cellmembrane is likely to function as a transporter? (Points : 2)

cholesterol
lipids
proteins
carbohydrates

Question 38.38. If potato slice is placed indistilled water, the cells would most likely __. (Points : 2)

lose water and becomelimp
neither take up water orlose water
take up water andswell
transport water into thecell by active transport.

Question 39.39. The chloroplast functions in___. (Points : 2)

protein synthesis
lipid storage
DNA replication
photosynthesis

Question 40.40. The fluid mosaic modelpresents the modern view of ___. (Points : 2)

the cell membranestructure
chromosome movementduring mitosis
protein synthesis
ATP production

Question 41.41. During which stage of mitosisdo nucleoli reappear and the nuclear membrane reforms? (Points :2)

prophase
metaphase
anaphase
telophase

Question 42.42. During which stage of mitosisdo chromatids separate to form two sets of daughter chromosomes?(Points : 2)

prophase
metaphase
anaphase
telophase

Question 43.43. Which of the following is thelongest stage of mitosis? (Points : 2)

prophase
metaphase
anaphase
telophase

Question 44.44. When during the cell cycle isDNA replicated? (Points : 2)

metaphase
Synthesis phase (S)
G1
cytokinesis

Question 45.45. A cell with 10 chromosomesundergoes mitosis and cell division. How many daughter cells areproduced and what number of chromosomes do they have? (Points :2)

4 daughter cells, 20chromosomes each
4 daughter cells, 5chromosomes each
2 daughter cells, 10chromosomes each
2 daughter cells, 5chromosomes each

Question 46.46. Maize (corn) has a haploidnumber of 10. How many chromosomes are in a zygote of maize?(Points : 2)

5
10
20
Not enough informationprovided

Question 47.47. Crossing over is one of themost important events in meiosis because __. (Points : 2)

homologous chromosomesare separated into different daughter cells
the number of chromosomesallotted to each daughter cell must be halved
sister chromatids must beseparated into different daughter cells
it produces new arrays ofalleles on chromosomes and contributes to genetic diversity

Question 48.48. While viewing stained onionroot tip cells you notice that distinct chromosomes cannot beobserved in most of the cells. This is because most of the cells___. (Points : 2)

were killed whilepreparing the slide
are in Interphase
are in metaphase
are undergoingMeiosis

Question 49.49. Each offspring cell producedby binary fission contains __. (Points : 2)

half the chromosomes ofthe original cell
twice as many chromosomesas the original cell
an independent assortmentof the original cell's chromosomes
an identical copy of theoriginal cell's chromosome.

Question 50.50. A DNA strand has the sequenceA-C-A-G-C-C-G-T-A. What would be its complementary strand? (Points: 2)

G-T-G-A-T-T-A-C-G
A-C-A-G-C-C-G-T-A
T-G-T-C-G-G-C-A-T
U-G-U-C-G-G-C-A-U

erinmoose680

A catabolic pathway would predictably result in the
A) reduction of a sugar.
B) synthesis of a macromolecule.
C) breakdown of a macromolecule.
D) breakdown of an atom.
2.
The drug Ritonavir is used to treat people with HIV/AIDS. It worksby binding to the active site of HIV-1 protease, an enzyme used bythe AIDS virus to create new proteins for production of newviruses.Once bound, the HIV-1 protease cannot produce proteins.Ritonavir can be classified as a(n)
A) competitive inhibitor.
B) allosteric inhibitor.
C) activator.
D) non-competitive inhibitor.
3.
During cellular respiration, __________ is the final electronacceptor that allows the regeneration of the cellâs supply of NAD+.In fermentation, ____________ is the final electron acceptor forNAD+ regeneration.
A) pyruvate / lactic acid
B) pyruvate / oxygen
C) ethanol / CO2
D) oxygen / pyruvate
4.
Which of the following clues would tell you if a cell isprokaryotic or eukaryotic?
A) whether or not the cell carries out cellular metabolism
B) the presence or absence of ribosomes
C) whether or not the cell is partitioned by internalmembranes
D) whether or not the cell contains DNA
5.
Phosphofructokinase (PFK) is an allosteric enzyme that regulatesglycolysis. When cellular concentrations of ATP and citrate become__________, this enzymeâs activity decreases. When cellularconcentrations of AMP become ________, the enzyme isactivated.
A) high / high
B) high / low
C) low / high
D) low / low
6.
______________ is an enzyme that can utilize the free energy in thehydrogen gradient (voltage) produced between the inner and outermembrane of the mitochondrion. The enzyme uses this energy toproduce ________.
A) ATP synthase/ ATP
B) PFK/ ATP
C) PFK/ glucose
D) ATP synthase/ ADP
7.
ATP is able to do cellular work because it
A) has a high energy phosphate bond that can be hydrolyzed torelease energy.
B) converts light energy into chemical bond energy.
C) contains the sugar ribose, which can provide additional energyfor a cell.
D) its hydrolysis is endergonic.
8.
A solution of starch at room temperature does not readily decomposeto form a solution of simple sugars because
A) the starch solution has less free energy than the sugarsolution.
B) the activation energy barrier for this reaction cannot besurmounted.
C) the hydrolysis of starch to sugar is endergonic.
D) starch hydrolysis is nonspontaneous.
9.
A person exposed to toxins would have more activity in their___________compared to an unexposed person.
A) lysosomes
B) Golgi bodies
C) rough endoplasmic reticulum
D) smooth endoplasmic reticulum
10.
Which of the following statements about fermentation is true?
A) The function of fermentation is to regenerate the fermentingcells' supply of NAD+.
B) Fermentation allows a fermenting cell to gain more energy perglucose molecule than a non-fermenting cell.
C) Fermentation produces either lactic acid or ethanol that thefermenting cell can use as an energy source.
D) Fermentation is a universal process that occurs in all cells andall organisms.
11.
A glucose molecule is completely broken down to carbon dioxide andwater in glycolysis and the citric acid (Krebs) cycle, but togetherthese two processes yield only a few molecules of ATP. Whathappened to most of the energy that the cell obtains from theoxidation of glucose?
A) It was lost as heat.
B) It is stored in the carbon dioxide and water molecules releasedby these processes.
C) It is stored in the ATP that was formed by glycolysis and thecitric acid cycle.
D) It is stored in NADH and FADH2
12.
The First Law of Thermodynamics states that
A) entropy tends to increase in a system.
B) entropy tends to decrease in a system.
C) energy cannot be created nor destroyed.
D) the quality of energy in the universe is decreasing.
13.
The endosymbiotic theory states that _______________ evolved as aresult of a symbiotic relationship between different types ofbacteria. _____________ is thought to be the selective factor thatmade this symbiosis advantageous.
A) mitochondria / A change in the Earthâs atmosphere from anaerobicto aerobic
B) endoplasmic reticulum / A decrease in the amount of foodavailable in the environment
C) chloroplasts / A change in the Earthâs atmosphere from aerobicto anaerobic
D) lysosomes / A decrease in the amount of food available in theenvironment
14.
A mutation in a fruit fly affects one of the proteins that pumphydrogen ions across the inner mitochondrial membrane; thismutation makes that particular protein function less efficiently.When comparing aerobic cellular respiration in this fly with awild-type fly, you would predict that the mutant fly would
A) produce less ATP than a wild-type fly.
B) show no difference in ATP production when compared to awild-type fly.
C) produce more ATP than a wild-type fly.
D) not be able to produce any ATP via aerobic cellularrespiration.
15.
Proteins that are destined to be exported from the cell have unique_________________ that are recognized by signal recognitionparticles and thus moved to the _________________ duringtranslation.
A) phosphofructokinases / nucleus
B) codons / rough endoplasmic reticulum
C) signal recognition sequences / rough endoplasmic reticulum
D) signal recognition sequences / free ribosomes
16.
During the Krebs cycle
A) NADH is oxidized.
B) ATP is produced.
C) pyruvate is produced.
D) Acetly CoA gains a carbon to form pyruvate.
17.
Why does the oxidation of organic compounds by molecular oxygen toproduce CO2 and water release free energy?
A) Electrons are being moved from atoms that have a lower affinityfor electrons (such as C) to atoms with a higher affinity forelectrons (such as O).
B) The electrons have a higher potential energy when associatedwith water and CO2 than they do in organic compounds.
C) The covalent bond in O2 is unstable and easily broken byelectrons from organic molecules.
D) The covalent bonds in organic molecules and molecular oxygenhave more kinetic energy than the covalent bonds in water andcarbon dioxide.
18.
In a chemical reaction, if ?G is negative, it means that thereaction is
A) exergonic, and work needs to be done for the reaction toproceed.
B) exergonic, and work can be done with energy released from thereaction.
C) endergonic, and work needs to be done in order for the reactionto proceed.
D) endergonic, and work can be done with energy released from thereaction.
19.
The energy for an endergonic reaction comes from a(n) ___________reaction.
A) ADP + P --> ATP
B) endergonic.
C) exergonic.
D) anabolic
20.
Glycolysis
A) involves catabolic reactions and ATP is produced.
B) involves anabolic reactions and ATP is produced.
C) involves catabolic reactions and creates energy.
D) involves anabolic reactions and creates energy.

BIL 255 Lecture Notes - Lecture 16: Mitochondrial Disease, Citric Acid Cycle, Electrochemical Gradient

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