BMB 401 Lecture Notes - Lecture 5: Oxaloacetic Acid, Enzyme Inhibitor, Insulin

30 views2 pages

Document Summary

Pyruvate + coa + nad+ acetyl-coa + co2 + nadh. This is the overall reaction catalyzed by pdc (pyruvate dehydrogenase complex) Step 1: e1 decarboxylates pyruvate and transfers the acetyl group onto its cofactor tpp and in the process co2 is eliminated. Step 2: e2 takes acetyl group from tpp and transfers it onto its cofactor lipoamide. Step 3: e2 transfers acetyl group from lipoamide to coa resulting in acetyl coa! In the process lipoamide is reduced to dihydrolipoamide e2 and the next 2 steps are done to regenerate lipoamide e2. Step 4: e3(ox)fad gets reduced and the disulfide bridge now becomes 2 thiol groups and does this to oxidize the dihydrolipoamide e2. It basically takes 2 h from dihydrolipoamidee2 and puts it on its disulfide bridge reducing it and oxidizing it back to lipoamide. Lipoamide e2 is regenerated but now we must regenerate the enzyme!

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents