MIC 301 Lecture Notes - Lecture 8: Measles, Croup, 6 Years

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Mic 301- lecture 8: rna viruses (that make us sick) (2/8/17) Non-enveloped single stranded rna containing virus: unique properties of human picornaviruses, virion is naked, small (25 to 30 nm) icosahedral capsid enclosing a single- stranded positive rna genome, genome functions as an mrna, picornaviruses, enterovirus. Types: poliovirus types 1, 2 and 3, coxsackie a viruses, coxsackie b viruses, echoviruses, enteroviruses. Transmission: human fecal matter, hand, sewage, water supply, solid waste landfills, water supply, shellfish. Pathogenesis of enterovirus infections: mouth, replication in oropharynx, primary viremia: blood stream, antibody blockage, target tissue, liver- hav- hepatitis, meninges- echo, polio, Encephalitis or paralytic disease: muscle- echo, coxsackie a, b- Heart (myocarditis, pericarditis) or thorax (pleurodynia: secondary viremia, skin, echo, coxsackie a, hand-foot-and-mouth disease, Liver, macrophage: primary viremia, secondary viremia, placenta, fetus, congenital infection, hepatitis c and hepatitis g are flaviviruses but not arthropod-borne viruses, hepatitis c virus.

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