MIC 321 Lecture Notes - Lecture 19: Epitope, Immunoglobulin Therapy, Immunoglobulin G
Document Summary
Autoimmunity gets worse with age due to epitope spreading. 2: production of different igg to different ec1 and ec2, get separation of skin cells and tight junctions, intermolecular epitope spreading with epitopes on same protein. 4: b cell in center and all types of autoreactive cd4 t cells to different things, h2 and h3 are usually hidden (cryptic epitopes) and got picked up and processed by b cells and leads to epitope spreading. Mixture of a lot of blood donors (mix igg of a lot of people) Need higher dose to be effective than when they used this therapy originally for people born with immunodeficiency with antibodies. Overabundance with igg = saturated so auto stuff cannot bind because they are all taken. 6: damage keeps occurring throughout life of the patient, total destruction of joints in the hand. Losing lot of t cells to periphery and losing lots of + and selection with shrinking of thymus.