MIC 321 Lecture Notes - Lecture 23: Transplant Rejection, Blood Transfusion, Type Iii Hypersensitivity

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 321
• Professor: Williams Roger

Document Summary

17: blood transfusion need to match antigens on rbcs and for solid organs need to match. 4: chronic rejection is type 3 and happens months or years after and mediated by igg, use anti b cell ab to treat the antibody complexes. 19: indirect pathway can induce b cells and ab and slide shows this. 26: steroids can also be used and prevent action of nfkb but many adverse side effects, slide 25 shows broad effects. Much less inflammation and less adhesion molecules. Reducing inflammation through cytokines and less lymphocytes going to transplanted organ: shows how t cell activation can be targeted by immunosuppressive drugs. 28 shows the effects of 2 drugs that are used and how they mess with t and b cells. 29: okt3 taken of market but was effective at depleting b cells, immune system can attack okt3 and cause type 3 hypersensitivity. 32 = summary of targets for immunosuppressive drugs.