MIC 323 Lecture 6: Test 2

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 323
• Professor: Schesser Kurt

Document Summary

8: rod shaped, not normal gram , grows slowly in lab and needs very sterile conditions, tough genetics and hard to knock out genes, gram + but has outer membrane = mom (mycobacterium outer membrane) Not related to om of gram evolutionarily. Convergent evolution = converged on same solution: my(cid:272)oli(cid:272) a(cid:272)ids alo(cid:374)g oute(cid:396) (cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e a(cid:396)e e(cid:395)ui(cid:448)ale(cid:374)t of lps (does(cid:374)(cid:859)t ha(cid:448)e a(cid:272)tual. Immunocompromised people get disseminated tb = most people with primary tuberculosis get better and have no further evidence of disease. During this activation we develop large lung cavities called granulomas: granulomas = skin lesions but it is a general term. Inflammation: collection of immune cells = organized collection of macrophages w/ characteristic morphology. Lecture 6: afte(cid:396) se(cid:395)ue(cid:374)(cid:272)i(cid:374)g (cid:449)as(cid:374)(cid:859)t lo(cid:374)g (cid:271)efo(cid:396)e (cid:449)e fou(cid:374)d (cid:448)i(cid:396)ule(cid:374)(cid:272)e fa(cid:272)to(cid:396)s. It mutates to become resistant = an adaptor. 15: mycobacterium is intracellular (compare to listeria and salmonella now) Listeria grabbed onto receptors and was dragged in taking advantage of already established receptor mediated entry.