MIC 323 Lecture Notes - Lecture 23: Staphylococcus, Superantigen, Glomerulonephritis

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 323
• Professor: Schesser Kurt

Document Summary

10 cytolytic toxins: toxins work like complement to disrupt the membrane. If you add a lot of toxin leads to necrosis which is bad uncontrolled death. Leaking of cellular contents: adding little of toxin leads to apoptosis and better death. Little membrane damage will get repaired and allow pathogen to take advantage of cell rather than just killing it quickly. We like this because works well with immune system and keeps stuff. 11 inside apoptotic bubble: structurally look just like macpf domain, bottom right pic shows one is cytolytic protein and other 2 are macpf domains. 12 exfoliative toxins: break down glue holding cells together. 13 enterotoxins: gut stuff like food poisoning and like vibrio toxin, pumps chloride toxins so water goes to gut. 14 toxic shock syndrome toxin 1: acts as superantigen. Lecture 23: binds and activates large classes of t cell in non-specific way. 16 types of disease: cutaneous.