PSIO 303A Lecture 40: Block 3 - Lecture 9 and 10 - Mitochondria 2_AF
29 Nov 2016
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Document Summary
Block 3 - lecture 9 and 10 - mitochondria 2. Know that mitochondria have other roles in addition to atp homeostasis. Know that mitochondria divide (fission) and degrade (mitophagy) in a lifecycle that is their own homeostasis. Recognize that mitochondria recognize some proteins and also import some proteins via tim and. Know that mitochondria play a role in triggering apoptosis mechanism. Understand the role of mitochondria as sensors in the pancreatic beta cell. They make a leak so instead of driving atp product via atp synthase, the protons leak back. Recognize the fact that there are many mitochondrial diseases. Allows mitochondria to synthesize new proteins coded by mtdna in the matrix. Autophagy is the cells" mechanism for disposing of large particles. Worn out mitochondria are broken down by lysosomes (via autophagy) Hydrolytic enzymes are introduced by fusion with a lysosomal vesicle. Er envelops mitochondrion ==> sealing of the envelope ==> merging with lysosome.
