PSY 302 Lecture Notes - Lecture 9: Basal Forebrain, Locus Coeruleus, Raphe Nuclei

• School: University of Arizona
• Department: Psychology Main
• Course: PSY 302
• Professor: Jean- Marc Fellous

Document Summary

5ht from the raphe nuclei (in the pons). Active during the transitions out of rem sleep histamines (tuberomammilary nucleus, hypothalamus): activate the cortex directly and indirectly (through basal forebrain ach). Anti-histamines promote drowsiness if release histamines neurons become active. Orexin (aka hypocretin, lateral hypothalamus): excitatory projections to cortex and many neuromodulatory centers. What makes us go/transition to sleep? adenosine hypothesis: adenosine accumulation during the awake period. Glycogen depletion leads to increase in adenosine which leads to progressive increase in general. Secreted by astrocytes which provide glycogen to neurons inhibition which leads to increase in sleep tendency. Destruction of leads to no sleep which leads to death. Stimulation of leads to drowsiness and delayed sleep. Mutual inhibition: vlpoa sends inhibitory projections to histamine, ne, 5ht, ach systems. Brain stem and forebrain arousal systems activated (ach, ne, 5ht, histamine) Can be unstable: narcolepsy, sleep attacks (low arousal state) sleep promoting region of vlpoa activated. Brain stem and forebrain arousal systems inhibited (sws)