BIOL 2443 Lecture Notes - Lecture 6: Creatine Kinase, Phosphocreatine, Glycogen

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20 Feb 2019
Department
Course
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BLOCK 2
Physiological Basics of Therapeutics
Lecture 13 (19): Muscle Tissue, Part 3
ATP and Muscle Contraction
o Sustained muscle contraction uses a lot of ATP energy
1 thick filament uses ~2500 ATP/s
o Muscles store enough energy to start contraction
o Muscle fibers must manufacture more ATP as needed
o ATP and CP Reserves
Adenosine triphosphate (ATP)
The active energy molecule
Creatine phosphate (CP)
The storage molecule for excess ATP energy in resting muscle
CREATININE = BY PRODUCT OF CREATINE PRODUCTION THAT IS
CLEARED/EXCRETED
MEASURE HOW fast we clear it out = measure of kidney function
o Energy recharges ADP to ATP
Using the enzyme creatine phosphokinase (CPK or CK)
Exists in cardiac muscles a lot in the blood stream = BAD SHIT
When CP is used up, other mechanisms generate ATP
o ATP Generation
Muscle cells use two main pathways to produce ATP
Aerobic metabolism of fatty acids in the mitochondria
Anaerobic glycolysis in the cytoplasm
o ATP Generation
Aerobic metabolismO2
Is the primary energy source of resting muscles
Breaks down fatty acids
Produces 34 ATP molecules per glucose molecule
Citric acid cycle ONLY AEROBIC
Anaerobic glycolysisNO O2
Is the primary energy source for peak muscular activity
Produces two ATP molecules per molecule of glucose
Breaks down glucose from glycogen stored in skeletal muscles
Perspective on, under
normal conditions, this
is the E we have stored
for use in muscle
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