BIOL 4041 Lecture Notes - Lecture 12: Phosphatidylinositol, Tas1R1, Tas1R2
Document Summary
3 kinds of papillae: foliate: cnx, circumvallate: cnix, fungiform: cnvii, different tastes are not con ned to speci c regions, 50-100 taste cells per taste bud. Lifetime of about 2 weeks (a lot of issues can occur in these cells because of interaction with outside environment: speci cally chemicals; if mutations occur, cell will die before problem effects other cells) How do molecules lead to sensations: these are epithelial in origin (modi ed skin cells) but contain many molecular components found in a neural axon, release vesicles into synaptic cleft with sensory afferent ber. Salty - nacl: na+ enters cells through selective cation channel, cell depolarizes, open voltage-gated ca2+ channels, ca2+ enters, ca2+ stimulates vesicle release, the food you eat, is the thing that depolarizes the cell. Sour - h: block k+ leak channels (salamanders) or enter cation-speci c channels (mammals, ek+ is very negative, so decreasing conductance leads to .
