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Lecture 33

BIOL 1082 Lecture Notes - Lecture 33: Human Leukocyte Antigen, Adaptive Immune System, Innate Immune System
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3 Pages
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Spring 2018

Department
Biological Sciences
Course Code
BIOL 1082
Professor
Mosley
Lecture
33

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Ch. 51 LO 3.20
Defenses against pathogens Textbook Reading: Concepts: 51.1-51.5 and pgs. 1081-1082
1. Describe the barrier and internal defenses that function as the innate immune system of
vertebrates. Explain why these are considered non-adaptive defenses.
Innate immune system: recognition of traits shared by broad ranges of pathogens, using
small set of receptors to bind molecules or structures. Activates internal defenses
enabling responses--nonspecific
Barrier Defense:
1. Skin, mucous membranes, secretions
Internal defenses:
1. Phagocytic cells, natural killers, Antimicrobial proteins, inflammatory response,
lysozyme, hemocrytes(phagocytosis), interferon
Not considered adaptive because adaptive occurs with tremendous specificity. Innate
immune system is to broad spectrum.
1. insects and invertebrates
2. List the four major characteristics of adaptive immunity and how they are brought about.
1-Response is antigen-dependent
2-There is a lag time between exposure and maximal response
3-Antigen-specific
4-Exposure results in immunologic memory
1. For each of the following molecules describe their composition, where they originate from, and
their function in adaptive immunity: Epitope, Antigen, MHC, Antibody, and Cytokines.
Epitope:
1. A molecular region on the surface of an antigen capable of eliciting an immune
response and of combining with the specific antibody produced by such a
response, antigenic determinant
Antigen:
1. Is any substance which provokes an adaptive immune response. [1] An antigen is
often foreign or toxic to the body (for example, a bacterium) which, once in the
body, attracts and is bound to a respective and specific antibody.
MHC
1. Is a set of cell surface molecules encoded by a large gene family in all vertebrates
which controls a major part of the immune system. MHC molecules mediate
interactions of leukocytes, also called white blood cells (WBCs), which are
immune cells, with other leukocytes or with body cells. MHC determines
compatibility of donors for organ transplant as well as one's susceptibility to an
autoimmune disease via cross reacting immunization. In humans, MHC is also
called human leukocyte antigen (HLA)
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Description
Ch. 51 LO 3.20 Defenses against pathogens Textbook Reading: Concepts: 51.151.5 and pgs. 10811082 1. Describe the barrier and internal defenses that function as the innate immune system of vertebrates. Explain why these are considered nonadaptive defenses. Innate immune system: recognition of traits shared by broad ranges of pathogens, using small set of receptors to bind molecules or structures. Activates internal defenses enabling responsesnonspecific Barrier Defense: 1. Skin, mucous membranes, secretions Internal defenses: 1. Phagocytic cells, natural killers, Antimicrobial proteins, inflammatory response, lysozyme, hemocrytes(phagocytosis), interferon Not considered adaptive because adaptive occurs with tremendous specificity. Innate immune system is to broad spectrum. 1. insects and invertebrates 2. List the four major characteristics of adaptive immunity and how they are brought about. 1Response is antigendependent 2There is a lag time between exposure and maximal response 3Antigenspecific 4Exposure results in immunologic memory 1. For each of the following molecules describe their composition, where they originate from, and their function in adaptive immunity: Epitope, Antigen, MHC, Antibody, and Cytokines. Epitope: 1. A molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response, antigenic determinant Antigen: 1. Is any substance which provokes an adaptive immune response. [1] An antigen is often foreign or toxic to the body (for example, a bacterium) which, once in the body, attracts and is bound to a respective and specific antibody. MHC 1. Is a set of cell surface molecules encoded by a large gene family in all vertebrates which controls a major part of the immune system. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. MHC determines compatibility of donors for organ transplant as well as ones susceptibility to an autoimmune disease via cross reacting immunization. In humans, MHC is also called human leukocyte antigen (HLA)
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