BIOL 2081C Lecture Notes - Lecture 26: Mitosis, Meiosis, Silent Mutation
Document Summary
Ensuring exact dna replication is essential promote organism survival. Dna is constantly bombarded by thermal collisions and uv light radiation, the damage from which must continuously be repaired. Some errors simply are proofread and repaired by dna polymerase. Other damage, such as tears or double-strand breaks, must be repaired by a more aggressive mechanism that results in the loss of genetic information. Reading assignment: hartl text, sections 14. 1, 14. 2, 14. 5, 14. 6, focusing on the los. Revisit hartl section 6. 8 if necessary (already covered in lecture #14) Videos, all optional viewing, but these do a good job of simplifying the concepts: Learning objectives: distinguish between mutations that are spontaneous or induced, germ-line or somatic, conditional or unconditional, and loss-of-function or gain-of-function. Spontaneous mutations: naturally" occurring mutations in the absence of mutagens. Induced mutations: mutations may be induced by exposure to uv light, radiation, extreme changes in temperature and by mutagenic chemicals; a mutation that comes about because of a mutagen.
