CHEM 4041 Lecture Notes - Lecture 9: Isocitrate Lyase, Citric Acid Cycle, Glyoxylic Acid
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17. 17: regulation of pyruvate dehydrogenase (pdh: phosphorylation switches off the activity, phosphorylation promoted w/ high nadh, atp, acetyl coa. Fig 17. 19: tca cycle control points: there are some observations linking some tca cycle enzymes to cancer suggesting that cancer is also a metabolic disease. Clicker: the control of the tca cycle is mainly by: allosteric enzymes. Fig 17. 20: a lot of intermediates and compounds that can be used in other cycles: alpha-ketoglutarate can be turned to amino acids! How is oxaloacetate replenished: carboxylation of pyruvate. Clicker: which of the following is a positive effector of isocitrate-dehydrogenase: adp. 17. 23: glyoxylate cycle: in plants and some microorganisms, isocitrate is not decarboxylated but instead cleaved by isocitrate lyase to form glyoxylate. Cac is a source of biosynthetic precursors: carboxylation by biotin-dependent enzyme. Clicker: starting with acetyl coa how much nadh is formed via the glyoxylate cycle: 1 molecule (reference gure 17. 23) Cac and human disease: most common diseases are severe form of encephalopathy.