BIO 479 Lecture Notes - Lecture 7: Beta Blocker, Clearance Rate, Cyclic Adenosine Monophosphate
Document Summary
Onenote online (cid:1006)/(cid:1013)/(cid:1005)(cid:1012): protei(cid:374) a(cid:374)d peptide hor(cid:373)o(cid:374)e regulatio(cid:374) Helps maintain its shape: membrane-bound receptor. Receptor for hormone on target cell, in/on the cell membrane. Receptor part sticking out of cell membrane called extracellular domain, within cell membrane is transmembrane domain, and the intracellular domain inside cell. It"s a protein: all proteins have shape, all proteins made through dna, so you must have the gene for this in order to have it. Extracellular domain is left unoccupied unless hormone is present. Intracellular domain has g-proteins (alpha, beta, and a y shaped symbol) attached to it and gdp+p (guanine-di-phosphate and inorganic phosphate) This type of receptor could be part of a synapse. Involved in ion gradient change (action potential, muscle contraction, etc) or to regulate cell reactions. Alpha isn"t the only g protein to move, it depends on what the signal is: called g proteins because dependent on guanine, hormone activation via protein kinase activation.