BIO 479 Lecture Notes - Lecture 14: Estriol, Estrone, Xenoestrogen

• School: University of Maine
• Department: Biology
• Course: BIO 479
• Professor: Rebecca Holberton

Document Summary

Wednesday, february (cid:401)8, (cid:401)(cid:399)(cid:400)8 9:(cid:402)(cid:400) am: direct or indirect interference, or exaggeration of hormone-regulated pathways, compounds can: Act in synergy with hormones (cid:336)to exaggerate signals(cid:337: estrogen receptor the root of many (cid:336)but not all(cid:337) problems, ddt and derivatives (cid:336)ddd, etc(cid:337) (cid:400)9(cid:403)8: paul muller-nobel prize ddt as insecticide: rachel carson. Ms in marine biology at johns hopkins. Jfk assembles commission later become sepa. (cid:400)97(cid:401) ddt banned in us: des (cid:336)diethylstilbestrol(cid:337) and thalidamide. Des sustain a pregnancy (cid:336)widely used(cid:337) (cid:400)9(cid:404)7 to (cid:400)96(cid:401) in uk, canada, japan, germany (cid:336)not us fda approved(cid:337) (cid:400)(cid:401),(cid:399)(cid:399)(cid:399) babies survived with phocomelia (cid:336)flipperlike arms or legs(cid:337: bisphenol a. Is found in cd"s, hard plastics, baby bottles, tooth selants, essentially everywhere. Fda - "problematic for developing embryos and young children" Exposure to small (cid:336)naturally occuring(cid:337) amounts of hormones can affect development: rats and mice, have a bicornate. "(cid:401) horns" uterus: sex sandwiched between other sexes can be "feminized" or "masculinized, endocrine disruption during critical steroid-dependent events during human development.