BMB 420 Lecture Notes - Lecture 4: Gram Staining, Stool Test, Hematemesis

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Sydney Segal
Case Study
Man with the rumbly tummy
Mr. Jones:
-50 years old with nausea and GI pain, dyspepsia
-Throwing up blood
Medical history:
Smoker (1-2 packs a day 15 years. Stopped 10 years ago), social drinker, no food intolerance
(cause inflammation), does not drink coffee (acidic drinks upset ulcers), Liberally uses aspirin
for knee and hip pain (can lead to erosion of mucus in stomach and cause ulcers).
Had this pain for about 1 month, last night had extreme pain. Vomiting blood for an hour
(hematemesis), coffee ground looking material in vomit. Dark, sticky, tar like stool (melenic
stool).
Diagnosis: endoscopy, stool sample, blood sample, biopsy, breath test
-Sees white tissue in stomach, indicative of ulcer
What is causing ulcer? Lets take a biopsy.
-lots of white blood cells.
-Damage on epithelial layer.
-inflammation (white blood cells), neutrophils in one area.
Do a gram stain of the biopsy, we see little Gram negative microbes, spiral bacteria. (Hylori), can
do Warthin stain (uses silver).
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Document Summary

50 years old with nausea and gi pain, dyspepsia. Stopped 10 years ago), social drinker, no food intolerance (cause inflammation), does not drink coffee (acidic drinks upset ulcers), liberally uses aspirin for knee and hip pain (can lead to erosion of mucus in stomach and cause ulcers). Had this pain for about 1 month, last night had extreme pain. Vomiting blood for an hour (hematemesis), coffee ground looking material in vomit. Diagnosis: endoscopy, stool sample, blood sample, biopsy, breath test. Sees white tissue in stomach, indicative of ulcer. Inflammation (white blood cells), neutrophils in one area.

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