BIOL 1020 Lecture Notes - Lecture 1: Neutrophil, Thrombus, Viscosity
22 Mar 2017
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Document Summary
Wbcs indices: diagnostic purposes, measure total number of circulating wbcs, leukocytosis: indicate cancer or infectious diseases, leukopenia: low level of wbcs, Megakaryocytes: huge cells that splinter into 2000 to 3000 fragments while still in the red bone marrow, each fragment enclosed with plasma membrane called platelets, platelets have vesicles but no nucleus, primary function is clotting. Platelets: more numerous than wbcs, formula: 150-400x10^3 mm^3, life span is 5 to 9 days, granules: contain chemicals that promote blood clotting once released. Hematopoiesis: blood formation: process which formed elements of blood is developed, in adults: formed in red bone marrow; from pluripotent stem cells, mature in bone marrow or lymphoid tissue. Erythropoiesis: production of rbcs, comes from myeloid stem cells: proerythroblast then reticulocyte (nucleus ejected) then rbc. Anemias: sickle-cell disease: autosomal recessive disorder; genetic defect in primary dna sequence leads to production of faulty hgb b chain and rbcs that take on a rigid sickle-cell shape.
