BI 322 Lecture Notes - Lecture 6: Glycosylphosphatidylinositol, Extracellular Matrix, Cell Membrane
29 Jan 2017
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Document Summary
Secondary structure can eliminate unfavorable interactions with hydrophobic tails. Stretch of approximately twenty amino acids that are hydrophobic. Detergent can move between plasma membrane and proteins. Pumps protons from one side of the cell to the other. Some hydrophilic and some hydrophobic amino acids. Studied most extensively in red blood cells. Spectrin network forms cortex in red blood cells. Many proteins tethered or restricted in lateral mobility. Proteins restricted to apical and basal domains of the membrane. Cells see antigens (sugars) they don"t recognize. Neutrophil rolls along the blood vessel wall. Additional interactions allow neutrophil to migrate into infected tissue. Non-homogeneous distribution of lipids in the plasma membrane. Certain lipids stick to other lipids more and interact with certain proteins more. Nuclear envelope and er may have evolved from invagination of plasma membrane. Information for transport contained in protein sequence. Lipids don"t spontaneously flip in the membranes. Higher levels of cholesterol mean less fluidity.
