BI 328 Lecture Notes - Lecture 4: Embryonic Stem Cell, Adult Stem Cell, Teratoma

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Hold potential to give rise to an array of cell types. Number of cell types that can be generated by a stem cell. Potential to give rise to an entire zygote. Only naturally occurring type of pluripotent cell. Capable of generating entire embryo, including all germ layers. When cell mass splits, can form twins. When part of mass is injected into an adult organism, a teratoma forms. A variety of tissue types can be seen in such a tumor. Initiate state of activation and proliferation under times of stress. Restricted to cells within those organ types. Often don"t divide, but are an immature state of the differentiated cell. Often located adjacent to or directly contacting another cell type. In direct contact, they are connected by cell to cell adhesion molecules. Some cells secrete factors that will promote/repress growth/proliferation/differentiation. Extracellular matrix also influences division states of cell. Daughter cells divide out of/are pushed out of the niche.

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