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Lecture 4

BIOL 3113 Lecture Notes - Lecture 4: Citric Acid Cycle, Atp Hydrolysis, Gastrointestinal Tract


Department
BIOL
Course Code
BIOL 3113
Professor
Barbara S
Lecture
4

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Metabolism
Biosynthesis
Macromolecules are made from subunits that are linked together in a condensation
reaction
The biosynthetic reactions require an energy input
Reducing power supplied by electrons donated by NADPH
Energy supplied by hydrolysis of ATP
Catabolism
Steps:
Digestion
*occurs in digestive tract/organelles
*provides small molecules
Glycolysis
*occurs in the cytosol
*does not require oxygen
*basis of anaerobic metabolism
Citric Acid Cycle
*occurs in matrix of mitochondria
*requires oxygen
Oxidative Phosphorylation
*driven by electron transport across the inner mitochondrial membrane
*generates ATP
*requires oxygen
Digestion
Enzymatic hydrolysis of macromolecules into their subunits:
Fats fatty acids
Polysaccharides monosaccharides
Polypeptides amino acids
Nucleic acids nucleotides
Hydrolysis = reverse of the dehydration reaction used to attach the subunits together:
Enzymes responsible: hydrolytic enzymes
Digestion takes place "outside" of the cell
Digestive tract (multicellular organisms), Digestive compartments (within cells)
Synthesis of nucleic acids, proteins and polysaccharides
Produced by the repeated addition of a subunit onto one end of a growing chain
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