BIOL 3113 Lecture Notes - Lecture 19: Globular Protein, Desmosome, Tubulin

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13 May 2020
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The cytoskeleton is an intracellular network of filament-forming proteins that control: *intermediate filaments (10 nm diameter) composed of various genetically related proteins. Various other proteins associated with the cytoskeleton that: Intermediate filaments - found in most animal cells. Tough, insoluble rope-like protein filaments, form a network extending from the perinuclear region to the cell periphery, often anchor to cell membrane at desmosomes (cell junctions) Exception: disassembly of nuclear lamin filaments during cell division. *monomers - elongated fibrous proteins: globular amino-terminal head, central rod, globular carboxyl-terminal tail. *dimers - two subunits associate side-by-side and coil around each other to form a coiled coil. *tetramers - two dimers associate in a staggered antiparallel manner => native subunit. *filament - large numbers of tetramers associated end-to-end and side-by-side in a helical manner to form a continuous filament. *keratins very diverse group of proteins (found in epithelial cells)

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